Synthesis and Photosynthesis-Inhibiting Activity of Some Anilides of Substituted Pyrazine-2-carboxylic Acids
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چکیده
Alkylation of pyrazine-2-carboxylic acid and 6-chloropyrazine-2-carboxylic acid with radicals generated by silver nitrate-catalyzed oxidative decarboxylation of pivalic acid afforded 5-(1,1dimethylethyl)pyrazine-2-carboxylic acid and 6-chloro-5-(l,l-dimethylethyl)pyrazine-2-carboxylic acid. Condensation of chlorides of the latter three halogenated and/or alkylated pyrazine-2carboxylic acids with ring-substituted anilines yielded a series of anilides of 6-chloropyrazine-2carboxylic, 5-(l,l-dimethylethyl)pyrazine-2-carboxylic or 6-chloro-5-(l,l-dimethylethyl)pyrazine-2carboxylic acids. Some of these anilides showed a moderate inhibitory effect upon the oxygen evo lution rate in spinach chloroplasts. The most active inhibitor was 5-chloro-2-hydroxyanilide of 6chloropyrazine-2-car boxy lie acid (IC50 = 0.008 mmol d m 3 ) . The introduction of chlorine in the pyrazine moiety led to an increased photosynthesis-inhibiting activity.
منابع مشابه
Synthesis and Antimycobacterial, Antifungal, and Photosynthesis-Inhibiting Evaluation of Some Anilides of Substituted Pyrazine-2-carboxylic Acids
Condensat ion of chlorides of subs t i tu ted pyrazine-2-carboxylic acids with r ing-subst i tu ted anilines yielded a series of anilides of 6-chloropyrazine-2-carboxylic, 5-( l , l -d imethyle thyl)pyrazine-2carboxylic or 6-chloro-5-(l , l-dimethylethyl)pyrazine-2-carboxylic acids. P r o d u c t s were tes ted for their ant imycobacterial , antifungal, and photosynthesis-inhibit ing activity. ...
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